Recenze Drug Selectivity

PART I. INTRODUCTION Polypharmacology in Drug Discovery PART II. SELECTIVITY OF MARKTETED DRUGS Kinase Inhibitors New Indications for Marketed Drugs Discovery Technologies of New Indications PART III. FIXED-DOSE COMBINATIONS The Growing Market of Fixed-Dose Combinations PART IV. UNSELECTIVE DRUGS IN DRUG DISCOVERY The Growing Importance of Individualising Drugs Drug Discovery Strategies for the Generation of Multi-Target Ligands against Neglected Tropical Diseases Designing-In Approach The Linker Approach (Drug-Conjugates) Merged Multiple Ligands Pharmacophore Generation of Multiple Ligands Cellular Assays PART V. THERAPEUTIC AREAS FOR DESIGNED MULTIPLE LIGANDS 5HT Transporter-Based Multiple Ligands for Depression Multiple Ligands Targeting the Angiotensin System for Hypertension PPAR-Based Multiple Ligands for Metabolic Disease Antibiotics Multiple Ligands in Cancer Therapy Multiple Ligands in Neurodegenerative Diseases schovat popis