FOREWORD 1. INTRODUCTION 2. PBPK, QSAR and TOXICITY PATHWAYS: CHEMICAL SCREENING AND PRIORITZATION TOOLS 3. COMPUTATIONAL RISK ASSESSMENT OF UNTESTED HAZARDOUS CHEMICAL AGENTS RELEASTED IN THE WATER ENVIRONMENT 4. RISK ASSESSMENT OF CHEMICAL MIXTURES 5. MODELING SENSITIVE SUB-POPULATIONS FOR RISK ASSESSMENT 6. COMPUTATIONAL METHODS FOR TOXICOGENOMIC ANALYSES FOR RISK ASSESSMENT 7. INTEGRATED SYSTEMS BIOLOGY APPROACHES TO PREDICTING DRUG-INDUCED LIVER TOXICITY 8. COMPUTATIONAL TRANSLATION AND INTEGRATION OF TEST DATA TO MEET RISK ASSESSEMENT GOALS 9. COMPUTATIONAL TRANSLATION OF DATA FROM NON-MAMMALIAN SPECIES TO MEET REACH INFORMATIONAL STRATEGIES 10. DEVLOPMENT OF IN SILICO TISSUE MODELS FOR RISK ASSESSMENT 11. EXAMPLES OF SIMULATIONS WITH A NEWLY DEVELOPED GENERIC PBTK -MODEL FOR INCORPORATING HUMAN BIOMONITORING DATA TO MEET REACH GUIDELINES 12. USE OF PUBLIC DATA SETS for RISK ASSESSMENT 13. COMPUTATIONAL TOXICOLOGY AND APPLICATIONS FOR RISK ASSESSMENTS OF PHARMACEUTICALS 14. DECISION FOREST: A NOVEL PATTERN RECOGNITION METHOD FOR IN SILICO RISK ASSESSMENT 15. TRANSLATION OF COMPUTATIONAL MODEL RESULTS 16. FUTURE RESEARCH NEEDS